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How are customer’s using the T cell exhaustion assay?
Although a key target for immune checkpoint blockade, exhausted T cell phenotypes are not well comprehended from a therapeutic point of view.
Immuno-oncology-based developers are looking to understand the pathways and molecular signatures governing the T cell exhaustion, in an effort to restore anti-tumour immunity.
Customers use our exhausted T cell exhaustion platforms to determine whether their therapeutic candidates can rescue or revitalize the functionality of the T cells in our human in vitro model, or when they are assessing their candidate’s ability to halt the progression of exhaustion, whereby their molecules are present during the in vitro exhaustion process.
In both approaches the T cells are phenotypically assessed by flow cytometry for expression of exhaustion markers, activation markers and any others deemed relevant to the mode of action of the customer’s molecules. Changes in cytokine production, proliferative response and functionality are all assessed to give the customer a clear understanding of how their molecule interacts and functions within a compromised tumour microenvironment model albeit an in vitro one.
The week will explore feelings of loneliness, its impact on our mental health and how we can all play a part in combating isolation within our community.
As scientists, we have an innate desire and duty of care to protect and prevent accidents and diseases. In doing so, we have developed a strong occupational safety and health (OSH) culture that values and safeguards our employees. Built on inclusion, we work together to find effective, appropriate, and sustainable solutions that promote the right to health and safety in the laboratory.
As agents of change, we’ve switched things up in the laboratory. To celebrate this period of change, we’ve sat down with Hannah Findlay to see how her secondment into the Research and Development (R&D) department aligns with the continual growth of Antibody Analytics.
As you’ve probably heard, Antibody Analytics is expanding, and so is our development opportunities. To celebrate our growth, we’ve sat down with a very talented lady who, with her hard work and determination, has attained a secondment in the Research and Development...
To celebrate our continual growth, we sat down with the team to see what ignited the move from academia to Antibody Analytics.
The 11th of March 2022 marks the start of British Science Week, a ten-day celebration of science, technology, engineering, and maths (STEM). This year, the theme is ‘growth,’ so it’s only fitting that we take you on a journey from the bench to the bedside and beyond.